Synthesis, in vitro antigiardial activity, SAR analysis and docking study of substituted chalcones
| Autor: | Manlio Graniel-Sabido, Rubén M. Carballo, Gumersindo Mirón-López, Rosa Moo-Puc, David Cáceres-Castillo, Gonzalo J. Mena-Rejón, Ramiro F. Quijano-Quiñones |
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| Rok vydání: | 2019 |
| Předmět: |
Chalcone
010405 organic chemistry Chemistry Stereochemistry Organic Chemistry medicine.disease_cause 01 natural sciences In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Docking (molecular) medicine Michael reaction Giardia lamblia Colchicine General Pharmacology Toxicology and Pharmaceutics Selectivity IC50 |
| Zdroj: | Medicinal Chemistry Research. 29:431-441 |
| ISSN: | 1554-8120 1054-2523 |
| Popis: | A series of 15 chalcones-bearing substituents at positions 2, 4, and 5 of rings A and B were synthesized using microwave-assisted Claissen–Smichdt condensation and evaluated for their activity against Giardia lamblia and Green monkey kidney cells. Five compounds exhibited activity against G. lamblia at IC50’s |
| Databáze: | OpenAIRE |
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