Heteroarylation of 6-Aryl-2,3-dihydroimidazo[2,1-b]thiazole withN-(Ethoxycarbonyl)heteroaromatic Salts

Autor:	David B. Staiger, Lendon N. Pridgen, Michael Anthony Mcguire, Louisa Lam Davis, Drake S. Eggleston, Ivan Lantos, S. C. Shilcrat, Lee Webb
Rok vydání:	1993
Předmět:	chemistry.chemical_compound chemistry Bicyclic molecule Aryl Organic Chemistry Quinoline Quinazoline Ethyl chloroformate Isoquinoline Phthalazine Thiazole Medicinal chemistry
Zdroj:	Journal of Heterocyclic Chemistry. 30:1663-1671
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570300634
Popis:	The ethyl chloroformate salts of a variety of benzo-fused six membered π-deficient heteroaromatics, including quinoline, isoquinoline, 4-chloroquinoline, 3-bromoquinoline, phthalazine, and quinazoline, reacted with 6-aryl-2,3-dihydroimidazo[2,1-b]thiazole at the 5-position. The dihydroheteroaromatic adducts were oxidized by o-chloranil, sulfur, or electrochemical methodology to form the 5-heteroaromatic-6-aryl- 2,3-dihydroimidazo[2,1-b]thiazoles (10-15). In each example, the regiochemistry of addition to the heteroaromatic ring was established
Databáze:	OpenAIRE
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