Synthesis, Characterization and Molecular Docking Studies of 5-Chloro-1-(1H-indole-2-yl)-3-methyl-4,5-dihydro-1H-pyrazole-4-carboxylic Acids

Autor:	G. Ganga Reddy, S. Ramakrishna Reddy, Ch. Venkata Ramana Reddy, E. Laxminarayana, B. Srinivasa Reddy
Rok vydání:	2022
Předmět:	General Chemistry
Zdroj:	Asian Journal of Chemistry. 34:1639-1643
ISSN:	0975-427X 0970-7077
Popis:	A series of new 5-chloro-1-(1H-indole-2-yl)-3-methyl-4,5-dihydro-1H-pyrazole-4-carbxylic acids (5a-c) was synthesized. For the synthesis of these compounds, the 1H-indole-2-carboxylic acids (1a-c) were used as core compound. The synthetic route leading to the title compounds is summarized in Scheme-I. The chemical structures of all intermediates and products were confirmed by their IR, 1H and 13C NMR, mass spectral data and elemental analysis. The molecular docking studies of title compounds was carried out to predict the binding interactions with target protein EGFR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1367d038cbf88c884bd659ffb8d335a0 https://doi.org/10.14233/ajchem.2022.23610 Zobrazit plný text záznamu