NMR Studies of Drugs. Phensuximide.1H and13C NMR Methods with Chiral Solvating Agents and Lanthanide Shift Reagents

Autor:	Kerry Sanders, Kunisi S. Venkatasubban, Robert Rothchild
Rok vydání:	1993
Předmět:	Lanthanide chemistry.chemical_element Carbon-13 NMR Atomic and Molecular Physics and Optics Analytical Chemistry Phensuximide NMR spectra database chemistry Computational chemistry Reagent medicine Organic chemistry Enantiomer Enantiomeric excess Europium Spectroscopy medicine.drug
Zdroj:	Spectroscopy Letters. 26:1997-2015
ISSN:	1532-2289 0038-7010
DOI:	10.1080/00387019308011648
Popis:	NMR spectra of the racemic anticonvulsant, phensuximide, 1, in CDCl3 solution, have been studied with additives to explore methods for potential direct determination of enantiomeric excess (% ee). Proton studies at 200 MHz with the chiral solvating agent (CSA) (-)-2,2,2-trifluoro-1- (9-recommended for ee analysis due to uncertainties of contributions to the NCH3 from the CH2 proton absorptions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::136642ba64a5967d145c6dfc8af82b7c https://doi.org/10.1080/00387019308011648 Zobrazit plný text záznamu