Synthesis of Trans- and cis-2-acetyl-3-phenyl-3,3a,4,5-tetrahydro-2H-benzo[g] Indazoles: Evaluation as Inhibitors of β-hematin Formation

Autor:	Lola De Lima, Jennifer L. Sánchez, Gricela Lobo, Daniel A. Aparicio, Ligia Llovera, Melina Monasterios, Jaime Charris, Jorge Angel, María E. Acosta
Rok vydání:	2017
Předmět:	010404 medicinal & biomolecular chemistry Indazole chemistry.chemical_compound chemistry 010405 organic chemistry Condensation Hydrazine Diastereomer General Chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences
Zdroj:	Journal of Chemical Research. 41:668-672
ISSN:	2047-6507 1747-5198
DOI:	10.3184/174751917x15105690662845
Popis:	Several trans- and cis-2-acetyl-3-(substituted-phenyl)-3,3a,4,5-tetrahydro-2 H-benzo[ g]indazole derivatives have been synthesised via the condensation of the appropriate exocyclic α,β-unsaturated ketones with hydrazine in hot acetic acid, to obtain diastereomeric mixtures of N-acetylated isomers. Structure elucidation was based on their spectral data and the trans–cis stereochemistry using of NOE and NOESY experiments. Biological testing of these derivatives as inhibitors of β-hematin formation was carried out.
Databáze:	OpenAIRE
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