Effect of Helicobacter pylori infection on cyclooxygenase-2 expression in gastric antral mucosa
| Autor: | Xiao-yu Chen, Wen-Zhong Liu, Yan Shen Peng, Shu Dong Xiao, Hong Lu |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Pathology biology business.industry Gastroenterology Chronic gastritis Inflammation Helicobacter pylori medicine.disease biology.organism_classification medicine.disease_cause Internal medicine biology.protein medicine Immunohistochemistry Cyclooxygenase medicine.symptom Gastritis business Carcinogenesis Antrum |
| Zdroj: | Chinese Journal of Digestive Diseases. 3:75-78 |
| ISSN: | 1443-9611 |
| DOI: | 10.1046/j.1443-9573.2002.00078_3_2.x |
| Popis: | OBJECTIVE: Helicobacter pylori infection is a major etiological cause of chronic gastritis. Inducible cyclooxygenase (COX-2) is an important regulator of mucosal inflammation. Recent studies indicate that expression of COX-2 may contribute to gastrointestinal carcinogenesis. The aim of this study was to investigate the effects of H. pylori infection and eradication therapy on COX-2 expression in gastric antral mucosa. METHODS: Antral biopsies were taken from 46 H. pylori-infected patients, who also had chronic gastritis, both before and after anti-H. pylori treatment. The COX-2 protein was stained by using immunohistochemical methods and COX-2 expression was quantified as the percentage of epithelial cells expressing COX-2. Gastritis and H. pylori infection status were graded according to the Sydney system. RESULTS: Cyclooxygenase-2 expression was detected in the cytoplasm of gastric antral epithelial cells both before and after the eradication of H. pylori. Cyclooxygenase-2 expression in mucosa with H. pylori infection was compared with the corresponding mucosa after successful H. pylori eradication (20.1 ± 13.1%vs 13.8 ± 5.9%; P < 0.05). At the same time, COX-2 expression in H. pylori-infected mucosa was compared with the normal controls (18.0 ± 14.1%vs 12.3 ± 4.6%, P < 0.05). Expression of COX-2 was correlated with the degree of chronic inflammation (r= 0.78, P < 0.05). CONCLUSIONS: Our results showed that H. pylori infection leads to gastric mucosal overexpression of COX-2 protein, suggesting that the enzyme is involved in H. pylori-related gastric pathology in humans. |
| Databáze: | OpenAIRE |
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