ELEVATED TRYPTASE, NERVE GROWTH FACTOR, NEUROTROPHIN-3 AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR LEVELS IN THE URINE OF INTERSTITIAL CYSTITIS AND BLADDER CANCER PATIENTS
| Autor: | Dianne Schmidt, Andrew L. Niles, Angela J. Okragly, Timothy D. Moon, Mary Haak-Frendscho, Thomas F. Warner, Randall L. Hoffman, Ricardo Saban, David T. Uehling |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Bladder cancer Urinary bladder biology business.industry Urology Urinary system Interstitial cystitis Tryptase medicine.disease Mast cell Endocrinology medicine.anatomical_structure Neurotrophic factors Internal medicine Glial cell line-derived neurotrophic factor biology.protein Medicine business |
| Zdroj: | Journal of Urology. 161:438-442 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(01)61915-3 |
| Popis: | Purpose: The 2 prominent features of interstitial cystitis are pain and increased numbers of mast cells in the bladder. In this pilot study we determined the concentration of soluble mediators associated with activation of sensory neurons and/or mast cells that were present in the urine.Materials and Methods: The study groups included 4 interstitial cystitis patients, 7 kidney donors with no history of bladder disease as negative controls, 6 bladder cancer patients and 7 patients with urinary tract infection as reference controls. Urine samples were assayed for different soluble mediators using immunoassays for tryptase (a marker for mast cell activation), neurotrophic factors (markers of neuronal plasticity) and chemokines (markers of inflammatory cell activity). Results were normalized based on creatinine concentration.Results: There was a marked increase in the average amounts of tryptase and 3 neurotrophic factors in patient urine. Interestingly, the mediator profile in the urine of bladder ca... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|