| Autor: |
Rona J. Strawbridge, Peter Vollenweider, Emily Sonestedt, Jingbo Zhao, Meena Kumari, Martina Mueller-Nurasyid, Vilmundur Gudnason, Denise K. Houston, Karina Meidtner, Nicholas J. Timpson, Daniel I. Chasman, Börge Schmidt, P. van der Harst, Leo-Pekka Lyytikäinen, Andrew Wong, Kaare Christensen, Qibin Qi, Karin Leander, Naveed Sattar, Henning Tiemeier, Paul M. Ridker, Ruth J. F. Loos, Johan G. Eriksson, Stella Trompet, Rita P. S. Middelberg, Terho Lehtimäki, Winfried Maerz, Juan P. Casas, Marc N. Jarczok, Aline Meirhaeghe, G Davey Smith, J. Tuomilehto, Kirsten Ohm Kyvik, Lars Ängquist, Mikael Thinggaard, Lars Christiansen, Nicholas J. Wareham, Pedro Marques-Vidal, Karl-Heinz Joeckel, Albert V. Smith, Rebecca Hardy, John Whitfield, Frank B. Hu, Krista Fischer, Anne U. Jackson, Heiner Boeing, Annette Peters, Sebastian E. Baumeister, Anne Tjønneland, Niek Verweij, Tiina Jääskeläinen, Max Vikström, Esther Zimmermann, Andres Metspalu, Tia Sorensen, Saira Saeed Mirza, Yoav Ben-Shlomo, Anders Hamsten, Mike A. Nalls |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Obesity Reviews. 16:327-340 |
| ISSN: |
1467-7881 |
| DOI: |
10.1111/obr.12263 |
| Popis: |
Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n = 169,551; 0.32 kg m(-2) ; 95% CI 0.28-0.32, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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