Unchartered waters: Significance of fall in Ki67 index after short-term preoperative endocrine therapy in early breast cancers

Autor: Dhanya Mary Louis, Lakshmi Malavika Nair, D.K. Vijaykumar, Archana George Vallonthaiel, Jyotsna Yesodharan, Renjitha Bhaskaran, M.P. Narmadha
Rok vydání: 2023
Předmět:
Zdroj: Breast Disease. 42:27-36
ISSN: 1558-1551
0888-6008
DOI: 10.3233/bd-220042
Popis: BACKGROUND: Endocrine treatment for breast cancer acts largely by inhibiting tumor cell proliferation. The biomarker Ki67 is linked to the proliferative index of the tumour. OBJECTIVE: To identify the factors affecting the fall in Ki67 value in early-stage hormone receptor (HR) positive breast cancer patients receiving short-term preoperative endocrine therapy in an Indian cohort. METHODS: Women with hormone receptor positive, invasive, nonmetastatic, and early breast cancer (4 week) did not affect the fall in Ki67. CONCLUSION: Preoperative therapy with Letrozole resulted in a more significant fall in Ki67, as compared to therapy with Tamoxifen. Determining the fall in Ki67 value in response to preoperative endocrine therapy could provide an insight into the response to endocrine therapy in luminal breast cancer.
Databáze: OpenAIRE
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