ChemInform Abstract: Practical, Asymmetric Synthesis of Aromatic-Substituted Bulky and Hydrophobic Tryptophan Derivatives
Autor: | Victor J. Hruby, Wei Wang, Jianqing Yang, Chiyi Xiong |
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Rok vydání: | 2010 |
Předmět: | |
Zdroj: | ChemInform. 33 |
ISSN: | 1522-2667 0931-7597 |
Popis: | An efficient method for the synthesis of novel aromatic substituted, bulky and hydrophobic tryptophan derivatives has been developed. Asymmetric hydrogenations of α-enamide 5 using Burk's DuPHOS-based catalysts generated high enantiomerically pure d - and l -α-amino acid derivatives 6 , which subsequently underwent Suzuki cross couplings with boronic acid derivatives to afford aromatic substituted tryptophan derivatives 7 and 8 in high yields. The method can allow for the preparation of such amino acids in large-scales for extensive structure–activity studies. |
Databáze: | OpenAIRE |
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