Epidemiology And Partial Nucleotide Sequence Of Four Novel Genital Human
| Autor: | Tracy Y. Zhang, Greg H. Eichinger, M. Michele Manos, Mark Schiffman, Jeffrey Waldman, Cosette M. Wheeler, Catherine E. Greer |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Nucleic acid sequence Cancer Biology medicine.disease Virology Molecular biology DNA sequencing law.invention chemistry.chemical_compound Infectious Diseases chemistry law Epidemiology medicine Immunology and Allergy Sex organ Human papillomavirus DNA Polymerase chain reaction |
| Zdroj: | Journal of Infectious Diseases. 170:1096-1099 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/170.5.1096 |
| Popis: | Polymerase chain reaction (PCR)-based genital human papillomavirus (HPV) detection methods that use consensus primers have enabled the broad-spectrum detection of most characterized HPV types. In addition, these techniques have allowed the identification of potentially novel viral sequences in clinical specimens. These methods were used to determine the partial L1 nucleotide sequence (the region generated by L1 consensus primers MY09 and MY11) of four novel viruses. The prevalence of these viruses in cytologically normal and dysplastic cervical specimens and in invasive cervical cancer was also determined. The partial DNA sequences of W13B (MM4), PAP291 (MM7), PAP155 (MM8), and PAP238a (MM9) are most similar to HPV-51, -61, -61, and -34, respectively. Prevalence studies suggest that W13B and PAP238a are cancer-associated, while PAP155 and PAP291 appear to be lower-risk viruses. |
| Databáze: | OpenAIRE |
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