Evidence against the presence of spare muscarinic receptors in the rabbit urinary bladder
| Autor: | Robert M. Levin, Janice High, Alan J. Wein |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
business.industry Urology Muscarinic acetylcholine receptor M3 Muscarinic acetylcholine receptor M2 Muscarinic acetylcholine receptor M1 Bethanechol Quinuclidinyl Benzilate chemistry.chemical_compound Endocrinology chemistry Internal medicine Muscarinic acetylcholine receptor Benzilylcholine mustard medicine Muscarinic acetylcholine receptor M4 Neurology (clinical) business medicine.drug |
| Zdroj: | Neurourology and Urodynamics. 2:317-321 |
| ISSN: | 1520-6777 0733-2467 |
| Popis: | In a recent study by Anderson and Marks [1982], indirect evidence was presented for the existence of “150-fold muscarinic receptor excess” in the rabbit urinary bladder. This conclusion was based on the quantitative comparison of the ability of carbamylcholine to both directly contract bladder strips and to inhibit (quinuclidinyl benzilate) binding. In order to investigate the presence of “spare receptors” in the bladder directly, we have determined the effect of benzilylcholine mustard (a noncompetitive cholinergic inhibitor) on both bethanechol stimulation of muscle-strip contraction and on [3H]QNB binding (muscarinic receptor density). The results of these studies indicate that there is no significant “muscarinic receptor excess” in the rabbit urinary bladder. |
| Databáze: | OpenAIRE |
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