Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study

Autor: Masaru Enomoto, Sang Bong Ahn, Chao Wu, Dae Won Jun, Jae Yoon Jeong, Li Liu, Htet Htet Toe Wai Khine, Lung-Yi Mak, Ming-Lun Yeh, Rui Huang, Mindie H. Nguyen, Seng Gee Lim, Chien-Hung Chen, Soung Won Jeong, Chia-Yen Dai, Jee-Fu Huang, Hyunwoo Oh, Sung Eun Kim, Wan-Long Chuang, Vivien W.M. Tsui, Rex Wan-Hin Hui, Dong Hyun Lee, Sabrina Quek, Ramsey Cheung, Man-Fung Yuen, Pei-Chien Tsai, Allen Dao, Eileen Yoon, Grace Lai-Hung Wong, Chung-Feng Huang, Daniel Q. Huang, Ritsuzo Kozuka, Yong Kyun Cho, Eiichi Ogawa, Joseph Hoang, Jae-Jun Shim, Lindsey Trinh, Qing Xie, Ming-Lung Yu, Cheng Yuan Peng, Hyoung Su Kim, Huy N. Trinh
Rok vydání: 2021
Předmět:
Zdroj: Hepatology International. 16:48-58
ISSN: 1936-0541
1936-0533
DOI: 10.1007/s12072-021-10271-x
Popis: We aimed to compare the longitudinal changes in estimated glomerular filtration rate (eGFR) in chronic hepatitis B (CHB) patients treated with entecavir (ETV) vs. tenofovir disoproxil fumarate (TDF). This is a retrospective study of 6189 adult treatment-naive CHB patients initiated therapy with TDF (n = 2482) or ETV (n = 3707) at 25 international centers using multivariable generalized linear modeling (GLM) to determine mean eGFR (mL/min/1.73 m2) and Kaplan–Meier method to estimate incidence of renal impairment (≥ 1 chronic kidney disease [CKD] stage worsening). We also examined above renal changes in matched ETV and TDF patients (via propensity score matching [PSM] on age, sex, diabetes mellitus [DM], hypertension [HTN], cirrhosis, baseline eGFR, and follow-up duration). In the overall cohort (mean age 49.7 years, 66.2% male), the baseline eGFR was higher for TDF vs. ETV group (75.9 vs. 74.0, p = 0.009). PSM yielded 1871 pairs of ETV or TDF patients with baseline eGFR ≥ 60 and 520 pairs for the eGFR
Databáze: OpenAIRE
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