UV spectrophotometric analysis for method development and validation of Beclofen

Autor:	Bindu Dhiman, Vishal Vats, Anju Dhiman, Saurabh Satija
Rok vydání:	2022
Předmět:	Renewable Energy Sustainability and the Environment General Chemical Engineering General Earth and Planetary Sciences General Chemistry General Agricultural and Biological Sciences Biochemistry General Environmental Science
Zdroj:	Research Journal of Chemistry and Environment. 26:55-61
ISSN:	2278-4527 0972-0626
DOI:	10.25303/2610rjce055061
Popis:	Baclofen is a γ-aminobutyric acid (GABA) close derivative which is primarily used in the treatment of spastic movement disorder. Estimation and determination of drug in any biological fluid, bulk and pharmaceutical formulation is important for safety, quality and therapeutics purpose which can be estimated by various methods including UV-visible spectroscopy, HPLC, colorimetry, solvent melting method etc. The main objective of this study was to develop and validate new UV-visible spectroscopy method for estimation of baclofen in HCL and phosphate buffer as per ICH guidelines. The UV spectroscopy method for the estimation of Baclofen was successfully prepared and validated with percentage recovery in the range of 97.41 – 102.62 %. The developed method was found to be precise, accurate, rugged and robust after evaluating the validation parameters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::13176d0192a350605de88549152a46ca https://doi.org/10.25303/2610rjce055061 Zobrazit plný text záznamu