1-[18F]Fluoroethyleneglycol-2-nitroimidazoles, a new class of potential hypoxia PET markers
| Autor: | W. Ehrlichmann, Hans-Juergen Machulla, Wolfgang Voelter, M. Übele, Raid J. Abdel-Jalil |
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| Rok vydání: | 2006 |
| Předmět: |
Stereochemistry
Health Toxicology and Mutagenesis Two step Public Health Environmental and Occupational Health Pollution Medicinal chemistry Analytical Chemistry Tetraethylene glycol chemistry.chemical_compound Nuclear Energy and Engineering chemistry Yield (chemistry) Alkoxy group Radiology Nuclear Medicine and imaging Fluoride Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 267:557-560 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-006-0086-9 |
| Popis: | 1-[2-(2-Fluoroethoxy)ethyl]-2-1H-nitroimidazole (3a), 1-{2-[2-(2-fluoroethoxy)ethoxy]ethyl}-2-1H-nitroimidazole (3b) and 1-(2-{2-[2-(2-fluoroethoxy)ethoxy]ethoxy}ethyl)-2-1H-nitroimidazole (3c) were synthesized in a two step sequence.Coupling the ditosylate of di-, tri- or tetraethylene glycol with 2-nitroimidazole followed by fluoride substitution afforded the reference compounds in high yield and18F labeling gave the corresponding markers in 70-82% radiochemical yield. |
| Databáze: | OpenAIRE |
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