AB0602 SYSTEMIC SCLEROSIS: SUBCLINICAL ATHEROSCLEROSIS AND MORBIMORTALITY

Autor: M. Martin Lopez, Patricia Carreira, M. Retuerto-Guerrero, B. Joven-Ibáñez, Julia Rosales
Rok vydání: 2020
Předmět:
Zdroj: Annals of the Rheumatic Diseases. 79:1597.2-1598
ISSN: 1468-2060
0003-4967
Popis: Background:Rheumatic diseases are associated with accelerated atherosclerosis, and an increase in cardiovascular morbidity and mortality. This process is mediated by classic cardiovascular risk factors (CVRF), chronic inflammation and atherogenic treatments such as corticosteroids. In Systemic Sclerosis (SSc) cardiovascular complications have increased in recent decades, although the studies on subclinical atherosclerosis (sATS) in SSc show discordant results.Objectives:To evaluate prospectively the relationship between subclinical atherosclerosis, cardiovascular morbidity and mortality in patients with SSc.Methods:120 consecutive patients with SSc who attended their medical regular review during November and December 2011 were included. We evaluated the presence of plaques and measured the right CCA IMT by B doppler US for the detection of sATS (IMT> 0.9mm and/or presence of plaque), review of classic CVRF and estimation of Medsger severity and EUSTAR activity index. Patients have been followed for 8 years, with at least annual consultation. In retrospect, the SCTC damage index, published in 2019, was obtained at the time of inclusion in the study. The clinical characteristics of the patients are collected since 1990 in a Prospective Longitudinal Observational Study (PLOS). Descriptive analysis was performed, using contigence tables for qualitative variables, and comparison of means for quantitative variables. The relationship between clinical characteristics, mortality, cardiovascular events (CVE), activity, severity and damage index, and sATS, was analyzed using binary logistic regression, adjusting for age and sex.Results:120 patients with SSc were included (93% female, age 60 ± 12 years). 42 of these patients (35%) had subclinical atherosclerosis. Age was statistically significant higher in patients with sATS compared to those without it (67.9±11.5 vs. 56.1±10.4 years, p Table 1.Relationship between clinical characteristics and activity, severity and damage index with the presence of accelerated atheromatosis.Absent n=78Present n=42Diffuse cutaneous SSc37.18%26.12%NSmRSS7.71 ± 6.326.38 ± 4.92NSHigh mRSS9.69 ± 8.337.57 ± 4.74NSArthritis32.05%28.57%NSLung involvement33.33%30.95%NSPAH10.26%7.14%NSCardiac involvement15.38%9.52%NSDigital ulcers35.90%35.83%NSAntiScl7025.64%21.43%NSESR20.12 ± 13.7726.88 ±17.25p =0.037*CPR0.65 ± 0.610.89 ± 0.7p =0.041*High activity index11.54%19.05%NSDamage index6.67 ± 5.565.62 ± 4.9NSΣ Medsger index5.37 ± 3.55.05 ± 3.45NSConclusion:In our study subclinical atherosclerosis is not related to higher mortality in patients with SSc, but it does seem to influence the occurrence of cardiovascular events. In addition, our results suggest that SSc does not influence the onset of accelerated atheromatosis.Acknowledgments:M Retuerto was recipient of a training grant from Sociedad Española de Reumatologia (SER).Disclosure of Interests:M. Retuerto-Guerrero: None declared, MARIA MARTIN LOPEZ: None declared, Beatriz Joven-Ibáñez Speakers bureau: Abbvie, Celgene, Janssen, Merck Sharp & Dohme, Novartis, Pfizer, José Luis Rosales Grant/research support from: I have received financial support from Novartis, UCB, Pfizer, Abvie to meeting and symposia, Patricia Carreira Grant/research support from: Actelion, Roche, MSD, Consultant of: GlaxoSmithKline, VivaCell Biotechnology, Emerald Health Pharmaceuticals, Boehringer Ingelheim, Roche, Speakers bureau: Actelion, GlaxoSmithKline, Roche
Databáze: OpenAIRE
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