Understanding tablet defects in commercial manufacture and transfer
| Autor: | Dean S. Murphy, Ian Gabbott, Catherine N. Hallam, Akmal H. Sabri, Baker Noel Alan Weldon |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Toughness
Materials science Drop (liquid) Pharmaceutical Science Modulus 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Microcrystalline cellulose 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breakage chemistry Drop tests Ultimate tensile strength Composite material 0210 nano-technology |
| Zdroj: | Journal of Drug Delivery Science and Technology. 46:1-6 |
| ISSN: | 1773-2247 |
| DOI: | 10.1016/j.jddst.2018.04.020 |
| Popis: | The effect of tablet tensile strength, drop height, number of drops and formulation on the propensity of tablet defects was investigated using modified tablet drop tests. It was found that increased drop height and number of drops increase the likelihood of tablet breakage; whilst increasing tablet tensile strength and using formulations with a high microcrystalline cellulose content provides some level of resistance against such defects. In addition, the present work highlights that common industrial tensile strength targets (1.7–2.0 MPa) may not, in some circumstances, be sufficient to prevent tablet defects during manufacture and transfer. Lastly, the current work also suggests that tensile strength, toughness and Young's modulus may not be suitable parameters in predicting the likelihood of tablet defects and damage arising. |
| Databáze: | OpenAIRE |
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