RELATIONSHIP OF PARAOXONASE 1 GENE POLYMORPHISMS AND CORONARY HEART DISEASE

Autor:	Wu Jiansheng, Zhang Xinxia, Chen Xiaoyan, Mo Yihao, Wu Fensheng
Rok vydání:	2012
Předmět:	Coronary angiography medicine.medical_specialty business.industry Statistical difference Coronary heart disease Surgery Internal medicine Paraoxonase 1 Gene Genotype Healthy control medicine In patient Cardiology and Cardiovascular Medicine business
Zdroj:	Heart. 98:E88.3-E89
ISSN:	1468-201X 1355-6037
DOI:	10.1136/heartjnl-2012-302920a.232
Popis:	Objectives The relationship of paraoxonase 1 gene polymorphisms and coronary heart disease has not been confirmed. This study aimed to detect PON-1 genotype (L55M and Q192R) in patients with coronary heart disease and compare with healthy control. Methods Consecutive patients underwent coronary angiography in our catheter laboratory in 2011 were recruited in CHD group or control group in accordance with the results of coronary angiography. L55M and Q192R genotype were detected in both groups by matrix-assisted laser desorption/ionisation time-of-flight mass spectrum (MALDI-TOF-MS). Results A total of 364 cases were recruited in CHD group, 90 cases enrolled in control group. In CHD group, 338 L55L, 26 L55M, 164 Q192R, 46 Q192Q, 154 R192R were detected. In control group, cases of L55L, L55M, Q192R, Q192Q, R192R were 87, 3,49, 13, and 28 respectively. There is no statistical difference between CHD group and control group by χ 2 test. R192R was higher in trend in CHD group (χ 2 measure 3.766, p=0.052). Conclusions Relationship between paraoxonase 1 gene polymorphisms and coronary heart disease has not been confirmed in this study, but a higher trend of R192R was found. Further investigation with larger volume focusing on the biological Significances of PON-1 genotype should be encouraged.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::130e73c14911a31f55d3c8f4e4f0e8d4 https://doi.org/10.1136/heartjnl-2012-302920a.232 Zobrazit plný text záznamu