The Extract of Edible Alga Petalonia binghamiae Suppresses TGF-β1-or H2O2-Induced Liver Fibrogenesis in LX-2 and HepG2 Cells
| Autor: | Seung-Il Jeong, In-Sun Park, Young-Ji Choi, Mi-Hee Kim, Bora Kwon, Kang-Yeol Yu, Seon-Young Kim, Ji-Young Kim, Young-Moo Choo, Ju Kim |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pharmacology Chemistry Liver fibrosis Plant Science General Medicine Microbiology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Complementary and alternative medicine Petalonia binghamiae Hepg2 cells Drug Discovery 030211 gastroenterology & hepatology Transforming growth factor |
| Zdroj: | Natural Product Communications. 13:1934578X1801300 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | Although the edible alga Petalonia binghamiae is extensively consumed as a health-promoting food by Northeast Asians, little is known about the biomedical efficacies of P. binghamiae. In this report, we investigated the novel efficacy of P. binghamiae extract ( Pb-E01) using LX-2 and HepG2 cells. Pb-E01 inhibited TGF-β1-induced cell proliferation and gene expression in LX-2 cells. In addition, Pb-E01 reduced H2O2–induced reactive oxygen species (ROS) and alanine aminotransferase (ALT) activity in HepG2 cells. According to these results, we suggest that Pb-E01 plays a functional role in suppressing liver fibrogenesis. |
| Databáze: | OpenAIRE |
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