Proliferative Response of Human T Lymphocytes to a Vaccinal Preparation of Ribosomes from Streptococcus pyogenes

Autor:	Isabelle Millet, Lucien Dussourd D'hinterland, Sergyl Lafont, Michèle Jeannin, Jean-Pierre Revillard, Gerard Normier
Rok vydání:	1988
Předmět:	Cellular immunity biology Immunology General Medicine T lymphocyte Ribosomal RNA biology.organism_classification medicine.disease_cause Streptococcaceae Ribosome In vitro Microbiology Streptococcus pyogenes medicine Immunology and Allergy Bacteria
Zdroj:	International Archives of Allergy and Immunology. 86:432-435
ISSN:	1423-0097 1018-2438
Popis:	The in vitro lymphocyte-activating properties of a ribosomal preparation of Streptococcus pyogenes were investigated. The preparation was mitogenic for human lymphocytes with a peak of 3H-thymidine incorporation occurring after 3–5 days of culture. The response was abolished by removal of CD3-positive cells and by alteration of accessory cells by exposure to L-leucine methyl ester. Most of the cells synthesizing DNA at the end of the culture expressed CD4 or CD8 but not CD20 antigens. No immunoglobulin synthesis was demonstrable. Although the same preparation was shown to be a T-independent polyclonal B-cell activator of murine cells, it preferentially triggers T cells in humans.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::130c9ec0ada28021b34fe509b28f5066 https://doi.org/10.1159/000234630 Zobrazit plný text záznamu