Quality by Design for Ciprofloxacin Encapsulation in PLGA Factors assessment followed by screening and optimization
| Autor: | Ionela Belu, Maria Viorica Ciocilteu, Valentin Costel Manda, Andreea Gabriela Mocanu, Johny Neamtu, Adina Turcu Stiolica, Claudiu Nicolicescu |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Materials Science (miscellaneous) Process Chemistry and Technology technology industry and agriculture General Engineering macromolecular substances General Chemistry General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses General Biochemistry Genetics and Molecular Biology Quality by Design Encapsulation (networking) Ciprofloxacin PLGA chemistry.chemical_compound chemistry Materials Chemistry medicine General Pharmacology Toxicology and Pharmaceutics medicine.drug Biomedical engineering |
| Zdroj: | Revista de Chimie. 69:1332-1338 |
| ISSN: | 2668-8212 0034-7752 |
| Popis: | The objective of this study is to formulate and characterize ciprofloxacin-PLGA nanoparticles in laboratory. Ciprofloxacin-PLGA nanoparticles were obtained with Ciprofloxacin and PLGA as raw materials at the room temperature. The optimum set of process parameters were determined using Design of Experiments (DoE) with the factors: PLGA concentration, Ciprofloxacin concentration, Agitation Rate and the responses: Particles Size, Ciprofloxacin Encapsulation. The optimized formulation had 36.83% Ciprofloxacin Encapsulation and 87.58nm Particles Size in the conditions of 10% PLGA Concentration, 24.8 mg Ciprofloxacin Concentration and 1500 Rpm. |
| Databáze: | OpenAIRE |
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