Antihypernociceptive effects of Petersianthus macrocarpus stem bark on neuropathic pain induced by chronic constriction injury in rats
| Autor: | Francis Desire Tatsinkou Bomba, Madhu Babu Battu, Gangadhar Matharasala, Perumal Yogeeswari, Dharmarajan Sriram, Télesphore Benoît Nguelefack, Albert Kamanyi, Ram Kumar Mishra |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Allergy business.industry Immunology medicine.disease Nitric oxide 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Nociception Allodynia chemistry Neuropathic pain Hyperalgesia Gene expression medicine Pharmacology (medical) medicine.symptom business 030217 neurology & neurosurgery Ellagic acid |
| Zdroj: | Inflammopharmacology. 29:1241-1253 |
| ISSN: | 1568-5608 0925-4692 |
| DOI: | 10.1007/s10787-021-00821-y |
| Popis: | Petersianthus macrocarpus (Lecythidaceae) stem bark is traditionally used in West and Central Africa for the treatment of boils and pain. The present study examined the chemical composition of the aqueous and methanolic stem bark extracts of P. macrocarpus by liquid chromatography–electrospray ionization–mass spectrometry (LC–ESI–MS) . Their antinociceptive effect was evaluated using chronic constriction injury (CCI)-induced neuropathic pain in a rat model. On the ninth day post-surgery, the pain perception (allodynia and hyperalgesia) of the animals was assessed after the administration of aqueous and methanolic extracts at the doses of 100 and 200 mg/kg. In addition, the effect of the extracts was evaluated on nitric oxide activity and on the expression of pro-inflammatory cytokines (TNF-α, IL-1β, and NF-κB). The LC–ESI–MS analysis revealed the presence of ellagic acid as the major constituent in the methanol extract. Both extracts at the employed doses (100 and 200 mg/kg), significantly (p |
| Databáze: | OpenAIRE |
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