Evidence of allograft related transplantation antigen binding cells for detection of cardiac allograft rejection—Preliminary report

Autor:	K. F. Lindenau, S. Vogt, R. Keitel, M. Werner, Otto U, S. Kiene
Rok vydání:	1992
Předmět:	Heart transplantation medicine.medical_specialty Pathology business.industry medicine.medical_treatment Azathioprine Immunosuppression Peripheral blood mononuclear cell Cardiac surgery Transplantation Regimen Antigen Immunology medicine Surgery business medicine.drug
Zdroj:	European Surgery. 24:29-31
ISSN:	1682-4016 0001-544X
DOI:	10.1007/bf02601999
Popis:	In 8 heart transplant recipients in follow-up checks we have evaluated the binding of transplantation antigen loaded methacrylate-carrier to peripheral mononuclear cells (rosette technique). All patients were treated with a triple-drug regimen for immunosuppression, consisting of steroids, azathioprine and cyclosporine A. The increase of the number of these antigen binding cells over a limit value of 30 RFC/103 MNC is a reliable sign of a beginning immune reaction against the graft. The evidence is given by comparing the results with these of situation in endomyocardial biopsies (EMB). The test is predictive 3 to 6 days before infiltrating cells are visible in biopsies and donor independent (use of antigen mixture from cadaver spleens).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::12ef1e9dfa01cc7de1b1cd68f9f2cda2 https://doi.org/10.1007/bf02601999 Zobrazit plný text záznamu Full text from SpringerLink