Chemical composition, antimicrobial and antimycobacterial activities of Aristolochia triangularis Cham. from Brazil
| Autor: | Marli Matiko Anraku de Campos, Alessandra O. Pereira, Fallon dos Santos Siqueira, Janaína M. de Ávila, Ionara I. Dalcol, Ademir F. Morel, Gabrielle do Carmo, Davi F. Back |
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| Rok vydání: | 2018 |
| Předmět: |
biology
Traditional medicine 010405 organic chemistry Chemistry medicine.drug_class Chloramphenicol Alkaloid biology.organism_classification Antimicrobial Antimycobacterial 01 natural sciences Terpenoid 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound medicine Shigella sonnei Agronomy and Crop Science Bacteria medicine.drug Nerolidol |
| Zdroj: | Industrial Crops and Products. 121:461-467 |
| ISSN: | 0926-6690 |
| Popis: | Three diterpenes (1, 4, 5), four lignans (2, 6, 7a, 7b), one sequiterpene (3) and one alkaloid (8) were isolated from an acidic ether fraction of Aristolochia triangularis Cham. native from Brazil. The compounds were identified as: ent-Kaur-16-en-19-al (1), zuonin B (2), nerolidol (3), (−)-Kaur-16-en-19-oic acid (4), ent-Kauran-16β,17-diol (5), dihydrocubebin (6), a mixture of α and β-cubebin (7a + 7b) and aristolactam BII (8). The methanol extract, fractions and the isolated substances were evaluated to check their antimicrobial/antimycobacterial activity against bacteria (14 strains), fungi (9 strains) and mycobacteria (3 strains). Shigella sonnei was highly susceptible to (−)-Kaur-16-en-19-oic acid (4), which showed a potency similar to the antibacterial substance chloramphenicol (MICs at |
| Databáze: | OpenAIRE |
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