Deracemization of (±)-mandelic acid using a lipase–mandelate racemase two-enzyme system

Autor:	Kurt Faber, Ulrike T. Strauss
Rok vydání:	1999
Předmět:	biology Stereochemistry Organic Chemistry Pseudomonas Mandelate racemase Mandelic acid biology.organism_classification Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Yield (chemistry) biology.protein Diisopropyl ether Physical and Theoretical Chemistry Lipase Racemization
Zdroj:	Tetrahedron: Asymmetry. 10:4079-4081
ISSN:	0957-4166
DOI:	10.1016/s0957-4166(99)00436-x
Popis:	Deracemization of (±)-mandelic acid was achieved by using a novel two-enzyme process consisting of: (i) Pseudomonas sp. lipase catalyzed O-acylation of (±)-mandelic acid in diisopropyl ether; followed by (ii) mandelate racemase catalyzed racemization of the remaining unreacted (R)-mandelic acid in aqueous buffer. When this one-pot sequence was repeated four times, (S)-O-acetylmandelic acid was obtained in 80% isolated yield and >98% ee as the sole product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::12bc836e6d1ca171761e5d6751478529 https://doi.org/10.1016/s0957-4166(99)00436-x Zobrazit plný text záznamu Full Text from ScienceDirect