Ribosomal resistance as a wide-spread self-defence mechanism in aminoglycoside-producingMicromonosporaspecies

Autor:	B. Matković, W. Piendl, August Böck
Rok vydání:	1984
Předmět:	biology Aminoglycoside Ribosomal RNA biology.organism_classification Microbiology Ribosome Biochemistry Sisomicin Verdamicin Genetics medicine Micromonospora Actinomycetales Molecular Biology Bacteria medicine.drug
Zdroj:	FEMS Microbiology Letters. 24:273-276
ISSN:	1574-6968 0378-1097
DOI:	10.1111/j.1574-6968.1984.tb01318.x
Popis:	The mechanism of self-defence against their own product was studied in five aminoglycoside-producing Micromonospora (M.) species: M. grisea (verdamicin producer); M. inyoensis (sisomicin producer); M. sagamiensis (sagamicin producer); M. rhodorangea (antibiotic G-418 producer) and M. zionensis (antibiotic G-52 producer). Analysis of cell-free extracts of these organisms showed that they were devoid of modification enzymes specific for aminoglycosides. They contained, however, high-level resistant ribosomes. Mixed subunit exchange experiments of ribosomes from the producer strains and from a sensitive non-producing species (M. melanosporea) demonstrated that it is the 30S subunit which confers resistance.
Databáze:	OpenAIRE
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