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1. 1. Behavioural experiments were carried out on grouped or individually housed rats, which assumed a daily dose of nimodipine (around 30 mg/kg/day). 2. 2. Two operant tests plus an open field session were made. In the “periodic conditioning” test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. In the “reversal” test the contingency for food delivery was switched four times from one lever to the other in a two lever Skinner box. 3. 3. In the “periodic conditioning” test, nimodipine treatment did not cause significant modifications in grouped rats. Isolated controls showed a depressed performance, which was overcome by nimodipine treatment. 4. 4. In the “reversal” test nimodipine treatment seemed to improve the cognitive performances of grouped and isolated rats. No differences were found between experimental groups in “open field” test. |
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