Persistent inflammation selectively activates opioid-sensitive phasic-firing neurons within the vlPAG

Autor:	Kylie B. McPherson, Courtney A. Bouchet, Basile Coutens, Susan L. Ingram
Rok vydání:	2023
Předmět:	Physiology General Neuroscience
Zdroj:	Journal of Neurophysiology. 129:1237-1248
ISSN:	1522-1598 0022-3077
Popis:	Intrinsic firing properties define four distinct vlPAG neuron populations, and a subset of each population expresses MORs coupled to GIRK channels. Persistent, but not acute, inflammation selectively activates opioid-sensitive Phasic vlPAG neurons. Although the vlPAG is known to contribute to the descending inhibition of pain, the activation of a single physiologically defined neuron type in the presence of persistent inflammation represents a mechanism by which the vlPAG participates in descending facilitation of pain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::12a054678f48a71ba23d62fd14f212c2 https://doi.org/10.1152/jn.00016.2023 Zobrazit plný text záznamu