Neuronal Counter of the Life Span: Does It Exist?
| Autor: | V. E. Dyakonova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0303 health sciences Cellular differentiation DNA replication Biology 01 natural sciences Genome Cell biology Telomere 03 medical and health sciences medicine.anatomical_structure medicine Epigenetics Neuron Mitosis Developmental biology 030304 developmental biology 010606 plant biology & botany Developmental Biology |
| Zdroj: | Russian Journal of Developmental Biology. 51:197-200 |
| ISSN: | 1608-3326 1062-3604 |
| DOI: | 10.1134/s1062360420030066 |
| Popis: | Dividing cells accumulate most of the mutations during DNA replication associated with mitosis. The telomere length is a well-known countdown counter for the age of a eukaryotic organism and of mutations potentially accumulated by its cells. The genome of neurons, i.e., nondividing cells, accumulates the greatest number of mutations after the completion of cell differentiation upon excitations of the neuron and epigenetic modifications of its genome activity. Neurons accumulate much more mutations than the dividing cells. Do neurons have their own counter of potentially accumulated mutations that independently determines the life span? |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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