Post‑COVID‑19 Syndrome in Outpatients: A Cohort Study

Autor: Florian Desgranges, Eliana Tadini, Aline Munting, Jean Regina, Paraskevas Filippidis, Benjamin Viala, Eleftherios Karachalias, Véronique Suttels, David Haefliger, Eleftheria Kampouri, Mathias Van Singer, Jonathan Tschopp, Laurence Rochat Stettler, Siméon Schaad, Thomas Brahier, Olivier Hugli, Yolanda Mueller Chabloz, Alexandre Gouveia, Onya Opota, Pierre-Nicolas Carron, Benoît Guery, Matthaios Papadimitriou-Olivgeris, Noémie Boillat-Blanco, RegCOVID Research Group
Rok vydání: 2021
Předmět:
Zdroj: SSRN Electronic Journal.
ISSN: 1556-5068
2020-0110
DOI: 10.2139/ssrn.3839467
Popis: Background: Some patients experience persistent symptoms after COVID-19, but data on outpatients with mild-to-moderate COVID-19 are scarce. We aimed to describe the post-COVID-19 syndrome in confirmed COVID-19 outpatients and to identify its predictors. Methods: This monocentric prospective cohort study included symptomatic outpatients with PCR-confirmed COVID-19 (COVID-positive) and SARS-CoV-2 negative PCR (COVID-negative). Predefined persistent symptoms were evaluated though a phone interview between more than three to ten months after diagnosis. Associations between long-term symptoms and PCR test result, as well predictors of persistent symptoms in COVID-positive were evaluated by multivariate logistic regression. Findings: The study population consisted mostly of young (median of 41 versus 36 years in COVID-positive and COVID-negative, respectively; p=0·020) health care workers (67% versus 82%; p=0·006). Persistent symptoms were reported by 223 (53%) COVID-positive and 33 (37%) COVID-negative ( p =0·006). Overall, 21% COVID-positive and 15% COVID-negative (p=0·182) consulted a doctor for these symptoms. Four surveyed symptoms were independently associated with COVID-19: fatigue (adjusted odds ratio [aOR] 2·14, 95%CI 1·04-4·41), smell/taste disorder (26·5, 3·46-202), dyspnea (2·81, 1·10-7·16) and memory impairment (5·71, 1·53-21·3). Among COVID-positive, female gender (aOR 1·67, 95% CI 1·09-2·56) and overweight/obesity (1·67, 1·10-2·56) were predictors of persistent symptoms. Interpretation: More than half of COVID-positive outpatients report persistent symptoms up to ten months after infection and 21% seek medical care for this reason. The symptoms and predictors of post-COVID-19 syndrome need further characterization as it places a significant burden on society and especially healthcare systems. Funding: This work was supported by an academic award of the Leenaards Foundation. Declaration of Interests: None to declare. Ethics Approval Statement: The project was approved by the Ethics Committee of the Canton of Vaud, Switzerland. All participants gave their verbal consent to participate in this study during the phone interview (project-ID CER-VD 2020-01107 and 2019-02283).
Databáze: OpenAIRE
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