Studies on the Synthesis of Di- and Trisaccharide Analogues of Moenomycin A. Modifications in Unit E and in the Lipid Part

Autor:	Guangbin Yang, Matthias Findeisen, Peter Welzel, Lothar Hennig, Sabine Giesa, Madina Mansourova, Ramona Oehme
Rok vydání:	2004
Předmět:	Inorganic Chemistry chemistry.chemical_classification chemistry Moenomycin A Stereochemistry Organic Chemistry Drug Discovery Trisaccharide Physical and Theoretical Chemistry Biochemistry Catalysis
Zdroj:	Helvetica Chimica Acta. 87:1807-1824
ISSN:	1522-2675 0018-019X
DOI:	10.1002/hlca.200490161
Popis:	Routes allowing the synthesis of moenomycin analogues with one modified sugar component and with new lipid parts were developed (see 10c, 12c, 16b, and 20b in Schemes 2–4). It is anticipated that such analogues will be useful for studying the mode of action of the moenomycin-type transglycosylase inhibitors in detail and for preparing analogues with improved pharmacokinetic properties.
Databáze:	OpenAIRE
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