Gastric Acid Responses to Graded i.v. Infusion of Pentagastrin and Histalog in Peptic Ulcer Patients before and after Antrum-bulb Resection
| Autor: | L. Palmer, Lars Olbe, U. Knutson, Bergegårdh S, G. Broman |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Gastric Acidity Determination business.industry medicine.medical_treatment digestive oral and skin physiology Gastroenterology digestive system diseases Pentagastrin Basal (phylogenetics) Pyloric Antrum Internal medicine medicine Gastric acid Gastrectomy business Antrum medicine.drug Gastrin |
| Zdroj: | Scandinavian Journal of Gastroenterology. 11:337-346 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/00365521.1976.12097116 |
| Popis: | Gastric acid responses to graded i.v. infusion of pentagastrin and Histalog were determined in peptic ulcer patients. Single-day multiple-dose tests were performed. The sensitivity to the humoral stimuli as determined by the calculated ED50's was not significantly different for duodenal ulcer patients with moderate (DUmod) or massive (DUmass) observed hypersecretion or for gastric ulcer (GU) patients: median ED50's of pentagastrin were 6.2, 6.6, and 13.1 mug/h in 18 DUmod, 22 DUmass and 7 GU patients respectively, and median ED50's of Histalog were 16.6, 25.3, and 17.1 mg/h in 14 DUmod, 10 DUmass and 6 GU patients respectively. Antrum-bulb resection significantly reduced basal acid secretion and maximal acid responses to the humoral stimuli (about 45% reduction) but did not significantly change the loss of gastric contents to the intestine or the sensitivity to the humoral stimuli (median ED50 of pentagastrin increased from 5.2 to 6.7 mug/h in 14 patients, and median ED50 of Histalog increased from 16.0 to 20.8 mg/h in 12 patients), suggesting that the intact antrum-bulb region of the ulcer patient is controlling the capacity to secrete acid, and indicating that antrum-bulb gastrin is an important trophic factor for the parietal cells in man. |
| Databáze: | OpenAIRE |
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