Antifungal susceptibility and test for cure of candida species among vulvovaginal candidiasis patients in a secondary care hospital, Nigeria
| Autor: | FE Emele, C.C. Ezeanya, Chinwe E Ejike, J. Dirisu, Charlotte Blanche Oguejiofor, N. R. Agbakoba |
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| Rok vydání: | 2017 |
| Předmět: |
Antifungal
Gynecology medicine.medical_specialty 030219 obstetrics & reproductive medicine medicine.drug_class business.industry General Chemical Engineering Antifungal drug Antimicrobial Symptomatic relief Surgery Secondary care 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine Vulvovaginal Candidiasis Vaginal swabs medicine 030212 general & internal medicine business |
| Zdroj: | African Journal of Clinical and Experimental Microbiology. 19:30 |
| ISSN: | 1595-689X |
| DOI: | 10.4314/ajcem.v19i1.5 |
| Popis: | Background: Antimicrobial resistance among Candida species is an intense public health concern. The aim of the study was to determine the antifungal susceptibility pattern and test for cure of Candida species among women of child bearing age who visited the General Hospital Onitsha, Nigeria with symptoms suggestive of Vulvovaginal Candidiasis (VVC). Materials and Methods: Eight hundred and seventy six female patients participated in the study of which high vaginal swabs were collected and evaluated mycological by standard microbiological methods: microscopic examination and culture using sabouraud dextrose agar (SDA). Susceptibility of isolates to 4 antifungal agents was tested using agar dilution method. Clinicomycological evaluation was also performed among the patients. Result : Higher minimum inhibitory concentration (MIC) to azole antifungals was observed predominantly among non-albicans Candida species increasingly involved in VVC. The rate of mycological resolution was higher than symptomatic relief at 2 weeks after treatment with antifungal drug. Conclusion : Efficacious treatment of VVC requires an adequate knowledge of the causative agents and more importantly the antimicrobial to which they exhibit high susceptibility. Keywords: Vulvovaginal Candidiasis, Clinico- mycology, Antimicrobial resistance, Candida species Susceptibilite antifonique et test pour la cure d'especes de candida entre les patients de candidases vulvovaginales dans un hopital de soins secondaires, Nigeria Contexte: La resistance aux antimicrobiens chez les especes de Candida est un probleme de sante publique intense. L'objectif de l'etude etait de determiner le schema de susceptibilite aux antifongiques et le test de guerison des especes de Candida parmi les femmes en âge de procreer qui ont visite l'hopital general de Onitsha, au Nigeria, avec des symptomes suggerant une candidose vulvovaginale (VVC). Materiaux et methodes: huit cent soixante-seize six patientes ont participe a l'etude des prelevements vaginaux eleves collectes et evalues par mycologie par methodes microbiologiques standard: examen microscopique et culture a l'aide de la gelose sabouraud dextrose (SDA). La susceptibilite des isolats a 4 agents antifongiques a ete testee en utilisant une methode de dilution en agar. Une evaluation clinico-mycologique a egalement ete realisee chez les patients. Resultat: une concentration minimale minimale d'inhibition (MIC) en anatoxines azoliques a ete observee principalement chez les especes non-albicans Candida de plus en plus impliquees dans VVC. Le taux de resolution mycologique etait plus eleve que le soulagement symptomatique a 2 semaines apres le traitement par un medicament antifongique. Conclusion : Un traitement efficace de la VVC necessite une connaissance adequate des agents causaux et, plus important encore, des antimicrobiens auxquels ils presentent une forte susceptibilite. Mots-cles : Candidiase Vulvovaginale, Clinico-mycologie, Resistance Antimicrobienne, Especes Candida |
| Databáze: | OpenAIRE |
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