Cytoprotective effects of dietary flavonoids against cadmium-induced toxicity

Autor:	Li Xiaoling, Liu Liu, Jianxia Sun, Lingmin Tian, Weibin Bai, Xinwei Jiang, Xia Li, Cuijuan Zhu
Rok vydání:	2017
Předmět:	0301 basic medicine DNA damage Inflammation 010501 environmental sciences Pharmacology 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Flavonols History and Philosophy of Science medicine heterocyclic compounds 0105 earth and related environmental sciences chemistry.chemical_classification Reactive oxygen species Lipid peroxide General Neuroscience fungi food and beverages carbohydrates (lipids) Metabolic pathway 030104 developmental biology chemistry Apoptosis Toxicity medicine.symptom
Zdroj:	Annals of the New York Academy of Sciences. 1398:5-19
ISSN:	0077-8923
DOI:	10.1111/nyas.13344
Popis:	Cadmium (Cd) damages the liver, kidney, bones, reproductive system, and other organs. Flavonoids, such as anthocyanins and flavonols, which are commonly found in plant foods, have shown protective effects against Cd-induced damage. The cytoprotective effects of flavonoids against Cd-induced diseases are mainly attributable to three mechanisms. First, flavonoids clear reactive oxygen species, thereby reducing lipid peroxide production and improving the activity of antioxidation enzymes. Second, flavonoids chelate Cd, thus reducing the accumulation of Cd and altering the levels of other essential metal ions in vivo. Third, flavonoids reduce DNA damage and inhibit apoptosis. In addition, flavonoids were found to inhibit inflammation and fibrosis and improve glycometabolism and the secretion of reproductive hormones. We introduce the daily dosage and absorption rate of flavonoids and then focus on their bioactive effects against Cd-induced toxicity and reveal the underlying metabolic pathway, which provides a basis for further study of the nutritional prevention of Cd-induced injury. In particular, a better understanding is needed of the structure-activity relationship of flavonoids against Cd toxicity, which has not yet been reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1287f7370fc66eb70d3db4aac175d74e https://doi.org/10.1111/nyas.13344 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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