Lipase-catalyzed asymmetric hydrolysis and regioselective bromination of 1,4-dihydropyridine. Synthesis of (R)-(=)-nilvadipine

Autor:	Hirosato Ebiike, Kazuo Achiwa
Rok vydání:	1994
Předmět:	biology Chemistry Organic Chemistry Triacylglycerol lipase Dihydropyridine Halogenation Regioselectivity Nilvadipine Medicinal chemistry Catalysis Inorganic Chemistry Hydrolysis medicine biology.protein Physical and Theoretical Chemistry Lipase medicine.drug
Zdroj:	Tetrahedron: Asymmetry. 5:1447-1450
ISSN:	0957-4166
Popis:	Homochiral ( R )-nilvadipine was synthesized from a prochiral substrate using lipase-catalyzed asymmetric hydrolysis and subsequent regioselective bromination as key steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1287a19464d410c521aca70511e4e8d8 https://doi.org/10.1016/0957-4166(94)80108-8 Zobrazit plný text záznamu