Effects of Electrical Stimulation of the Cerebellum and Injections of Levetiracetam on Aggressive Behavior of Kindling Rats

Autor:	V. V. Godovan, E. V. Kobolev, T. M. Muratova, L. S. Godlevsky
Rok vydání:	2014
Předmět:	Cerebellum medicine.anatomical_structure Physiology Kindling business.industry General Neuroscience Anesthesia Cortex (anatomy) medicine Stimulation Levetiracetam business medicine.drug
Zdroj:	Neurophysiology. 46:381-383
ISSN:	1573-9007 0090-2977
DOI:	10.1007/s11062-014-9459-9
Popis:	In rats with the corazole-induced kindling syndrome, we estimated the conditions for the appearance of battles on an electrified floor; the threshold for initiation of aggressive reactions in kindling animals was lower, on average, by 41.5%, as compared with the corresponding index in intact animals. Combination of electrical stimulation (ES) of the paleocerebellar cortex (lobules V-VII; 100 sec–1; altogether 10 sessions of ES) and injection of levetiracetam (40.0 mg/kg, i.p.), which per se did not influence significantly aggressive behavior of kindling rats, led to an increase in the threshold for the appearance of battles, on average, by 28.8% (P < 0.05), compared with the initial value in the tested animals, i.e., to a drop in the level of aggressiveness.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::126969200cc54e6a7a6e075188bc9fd8 https://doi.org/10.1007/s11062-014-9459-9 Zobrazit plný text záznamu Plný text ve formátu PDF