Hepatitis G virus infection in Chinese patients with chronic hepatitis B, C or non-A-E: clinical and molecular aspects
| Autor: | Hubert E. Blum, Zhenya Tang, Josef Köck, Dongliang Yang, Darius Moradpour, Lian Jie Hao |
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| Rok vydání: | 1999 |
| Předmět: |
Hepatitis B virus
Hepatitis Hepatology biology business.industry Hepatitis C virus Hepacivirus virus diseases Hepatitis C medicine.disease_cause medicine.disease biology.organism_classification Virology digestive system diseases Infectious Diseases Orthohepadnavirus Hepadnaviridae Immunology medicine Coinfection business |
| Zdroj: | Hepatology Research. 13:133-142 |
| ISSN: | 1386-6346 |
| Popis: | In the present study we investigated the epidemiology, clinical significance and molecular characteristics of hepatitis G virus (HGV) infection in Chinese patients with chronic hepatitis B, C or non-A-E. Based on the detection of HGV RNA by reverse transcription polymerase chain reaction, 17 of 70 patients (24%) with chronic post-transfusion hepatitis C were coinfected with HGV. In contrast, none of 21 patients with non-A-E hepatitis had detectable HGV RNA. Among nine patients with severe chronic hepatitis caused by HBV/HCV coinfection, two were HGV RNA positive without affecting the outcome. Sustained biochemical response to interferon-alpha was similar in patients with HCV infection only (22/51, 43%) and in patients with HCV/HGV coinfection (7/17, 41%). Among ten Chinese HGV isolates, the nucleotide sequence homology in the 5′-UTR was 91–100% as compared to 84–95% between the Chinese HGV isolates and those from other countries. No core gene was found in the Chinese HGV isolates examined. In conclusion, about 20% of Chinese patients with chronic hepatitis C are coinfected with HGV. Coinfection did not affect the natural course of chronic hepatitis C or the response to antiviral therapy. Sequence analyses revealed a high degree of homology among Chinese HGV isolates. HGV infection does not appear to play a major clinical role in Chinese patients with chronic hepatitis B, C or non-A-E. |
| Databáze: | OpenAIRE |
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