Amine-Tunable Ruthenium Catalysts for Asymmetric Reduction of Ketones

Autor:	Xingzhong Zeng, Frederic G. Buono, Sonia Rodriguez, Keith R. Fandrick, Shengli Ma, Yibo Xu, Bo Qu, Melissa A. Herbage, Nizar Haddad, Zhengxu S. Han, Nathan K. Yee, Heewon Lee, Chris H. Senanayake, Nelu Grinberg
Rok vydání:	2014
Předmět:	Chemistry Asymmetric hydrogenation Enantioselective synthesis Noyori asymmetric hydrogenation chemistry.chemical_element General Chemistry Transfer hydrogenation Combinatorial chemistry Catalysis Ruthenium chemistry.chemical_compound Organic chemistry Chirality (chemistry) Phosphine
Zdroj:	Advanced Synthesis & Catalysis. 356:301-307
ISSN:	1615-4150
Popis:	A series of efficient ruthenium catalysts has been developed for the asymmetric hydrogenation and transfer hydrogenation of ketones with high reactivities and selectivities. The new chiral bisdihydrobenzooxaphosphole (BIBOP)/diamine-ruthenium complexes catalyzed the enantioselective hydrogenation of substrates such as aryl and heteroaryl cyclic and alkyl ketones with substrate/catalyst (S/C) ratios of up to 100,000. The opposite sense of enantioselectivity can be obtained by proper selection of a diamine with a given chirality of the phosphine. The usefulness of the new system has been demonstrated in the asymmetric hydrogenation of a complex synthetic intermediate towards cholesteryl ester transfer protein (CETP) inhibitors at S/C 20,000 on large-scale operation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::125ea2b91a7b9540d5d7e75e89ebd22b https://doi.org/10.1002/adsc.201300727 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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