| Popis: |
Apigenin, an important flavones, belongs to the subclass of flavonoids. Apigenin proved its potency towards different dreadful pathophysiological conditions, including diabetes and cancer which share their risk factors to complement each other and are the major causes of mortality worldwide. Apigenin is found to be effective in different in vitro cellular studies and also in different in vivo systems. It has the protective efficiency to counteract the deregulation of cell cycle at different checkpoints, autophagy, apoptosis and neurodegeneration. The mechanism of action of apigenin so far convinced the scientific world towards its acceptance as an anticancer and antidiabetic agent which also favours the usefulness of apigenin nanoformulations to be used as modern therapeutic tool. However, poor water solubility and non-specificity towards its target tissues have been successfully overcome by using various nanocarriers of apigenin. This chapter will focus on the array of biological activities of apigenin and address the issues of delivering apigenin through nanocarriers to improve the efficacy of apigenin, more particularly in diabetes and various types of cancer. |
