CROSS-LINKS MULTISCALE EFFECTS ON BONE ULTRASTRUCTURE BIOMECHANICAL BEHAVIOR
| Autor: | Tesnim Kraiem, Abdelwahed Barkaoui, Tarek Merzouki, Moez Chafra |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chemistry Biomedical Engineering 02 engineering and technology 021001 nanoscience & nanotechnology Fibril 03 medical and health sciences 030104 developmental biology Rigidity (electromagnetism) Bone ultrastructure Ultrastructure Biophysics Organic matrix Microfibril 0210 nano-technology |
| Zdroj: | Journal of Mechanics in Medicine and Biology. 18:1850062 |
| ISSN: | 1793-6810 0219-5194 |
| DOI: | 10.1142/s0219519418500628 |
| Popis: | Bone is a multiscale combination of collagen molecules merged with mineral crystals. Its high rigidity and stability stem amply from its polymeric organic matrix and secondly from the connections established between interdifferent and intradifferent scale components through cross-links. Several studies have shown that the cross-links inhibition results in a reduction in strength of bone but they do not quantify the degree to which these connections contribute to the bone rigidity and toughness. This report is classified among the few works that measure the cross-links multiscale impact on the ultrastructure bone mechanical behavior. This work aims firstly to study the effect of cross-links at the molecule scale and secondly to gather from literature studies results handling with cross-links effects on the other bone ultrastructure scales in order to reveal the multiscale effect of cross-links. This study proves that cross-links increasing number improves the mechanical performance of each scale of bone ultrastructure. On the other hand, cross-links have a multiscale contribution that depends on its rank related to existing cross-links connecting the same geometries and it depends on mechanical characteristics of geometries connected. |
| Databáze: | OpenAIRE |
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