SODIUM TAUROCHOLATE-INDUCED ACUTE PANCREATITIS IN PIGS
| Autor: | J. O. Stadaas, B. Lium, Pillgram-Larsen J, T. E. Ruud, Ansgar O. Aasen |
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| Rok vydání: | 2009 |
| Předmět: |
Pancreatic duct
medicine.medical_specialty Pancreatic disease General Immunology and Microbiology medicine.drug_class business.industry General Medicine Abdominal cavity medicine.disease Gastroenterology Endocrinology medicine.anatomical_structure Immunology and Microbiology (miscellaneous) Internal medicine medicine Corticosteroid Acute pancreatitis Pancreatitis Aprotinin business Pancreas medicine.drug |
| Zdroj: | Acta Pathologica Microbiologica Scandinavica Series A :Pathology. :377-382 |
| ISSN: | 0108-0164 |
| Popis: | Acute pancreatitis was induced in anesthetized pigs by injection of Na-taurocholate into the pancreatic duct. The pigs were allocated to 4 groups. One group remained untreated while the other groups received either C1-inhibitor, aprotinin or methyl-prednisolone intravenously as pretreatment. Extensive necroses of the pancreatic parenchyma, peripancreatic oedema and accumulation of large amounts of fluid in the abdominal cavity developed within a few hours in all experimental groups. Pretreatment significantly improved hemodynamics and increased the survival rate at 6 hours. It is concluded that the most essential effect of the pretreatments were reduction of proteolytic activities which are secondary to the pancreatic lesions. |
| Databáze: | OpenAIRE |
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