Anti-Inflammatory Activity of Hemantane on Peripheral Inflammation and Lipopolysaccharideinduced Neuro-Inflammation Models

Autor:	E. A. Ivanova, T. A. Voronina, Nepoklonov Av, I I Kokshenev, I. G. Kapitsa, E A Val'dman
Rok vydání:	2014
Předmět:	Pharmacology Parkinson's disease Lipopolysaccharide medicine.drug_class Antiparkinsonian drug Peritonitis Inflammation medicine.disease Anti-inflammatory Peripheral Neuro inflammation chemistry.chemical_compound chemistry Drug Discovery medicine medicine.symptom
Zdroj:	Pharmaceutical Chemistry Journal. 47:517-520
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-014-0994-x
Popis:	Hemantane is a novel antiparkinsonian drug that is undergoing clinical trials. Hemantane in the dosage range 10 – 40 mg/kg demonstrated anti-inflammatory activity and decreased statistically significantly the intensity of the exudative reaction in an acetic-acid peritonitis model in mice. Hemantane (10 mg/kg) in a neuro-inflammation model induced by lipopolysaccharide injection in rats prevented loss of body mass, development of forepaw akinesia contralateral to the operation, and smell disturbance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::124c6ab0aaa4477262db610afdc7d29e https://doi.org/10.1007/s11094-014-0994-x Zobrazit plný text záznamu Plný text ve formátu PDF