| Autor: |
Pablo Sanchez, Zachery Lewald, Pavel Prusakov, Jacqueline Magers, Matthew Kielt, Concepcion de Alba Romero, Natalie White, Randy Miller, Richard Moraille, Anthony Thiele |
| Rok vydání: |
2023 |
| Popis: |
Objective. To determine the adherence and safety outcomes of a 5-day antibiotic course with a “time-out” for treatment of “blood culture-negative” pneumonia in the NICU Study design. Prospective surveillance of all infants diagnosed with pneumonia at 7 NICUs from 8/2020-12/2021. Safety outcomes were defined a priori by re-initiation of antibiotic therapy within 14 days after discontinuation and overall and sepsis-related mortality. Results. 128 infants were diagnosed with 136 episodes of pneumonia; 88% (n=119) were treated with 5 days of definitive antibiotic therapy. Antibiotics were restarted within 14 days in 22 (16%) of the 136 pneumonia episodes. Mortality was 5% (7/128); 5 of the 7 deaths were assessed as sepsis-related. There was no difference in the combined safety outcomes of antibiotic restart or mortality between ≤5 and 6-20 days of definitive antibiotic treatment. Conclusion. Adherence to the 5-day definitive antibiotic treatment for “culture-negative” pneumonia was high and the intervention seemed safe. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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