SKIN PERMEATION ENHANCEMENT BY FATTY ACIDS
| Autor: | Hanafi Tanojo, Hans E. Junginger |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Chromatography Polymers and Plastics Double bond Chemistry food and beverages Fatty acid Penetration (firestop) Permeation Surfaces Coatings and Films medicine.anatomical_structure Saturated fatty acid Stratum corneum medicine Organic chemistry Physical and Theoretical Chemistry Monounsaturated fatty acid Polyunsaturated fatty acid |
| Zdroj: | Journal of Dispersion Science and Technology. 20:127-138 |
| ISSN: | 1532-2351 0193-2691 |
| DOI: | 10.1080/01932699908943782 |
| Popis: | The present study elucidates the skin permeation enhancement effects of a number of fatty acids, i.e. straight-chain saturated (SFA), monounsaturated (MUFA) and polyunsaturated acids (PUFA). The effects were studied using human stratum corneum (SC) and p-aminobenzoic acid (PABA) as a model permeant. The fatty acids in propylene glycol (FA/PG) were applied according to a pre-treatment/co-treatment protocol. SFA with 6 to 12 carbons exhibit a parabolic correlation between enhancement effect and chain-length, with a maximum at nonanoic-decanoic acids (with 9 and 10 carbons). All cis-6-, 9-, 11- or 13-octadecenoic acids (MUFA) enhance the permeation of PABA to the same extent. PUFA — linoleic (LA), α-linolenic (ALA) and arachidonic acids — enhance PABA permeation stronger than MUFA but additional double bonds do not further increase the degree of enhancement. The enhancement effects of fatty acids on the PABA penetration through SC are structure-dependent, associated with the existence of a balance b... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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