Penioxalamine A, a novel prenylated spiro-oxindole alkaloid from Penicillium oxalicum TW01-1

Autor:	Xin Wu, Xiqing Bian, Yue-Hu Pei, Jiao Bai, Hui-Ming Hua, Xiaolan Hu, Aihong Han, Jian-Yong Li
Rok vydání:	2014
Předmět:	Penicillium oxalicum chemistry.chemical_compound Prenylation Chemistry Stereochemistry Alkaloid Organic Chemistry Drug Discovery Oxindole Cytotoxicity Spectral data Biochemistry
Zdroj:	Tetrahedron Letters. 55:3864-3867
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.05.104
Popis:	Penioxalamine A (1), a novel prenylated spiro-oxindole alkaloid having a unique seven-membered nitrogen heterocycle system, was isolated from the fungus Penicillium oxalicum TW01-1. The structure of 1 was elucidated on the basis of the spectral data, single-crystal X-ray diffraction, and CD analysis. Compound 1 showed moderate cytotoxicity against HL-60 cell line. The possible biosynthetic pathway of 1 was also proposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::122e1528e8a98f862070ee57b9c8fcfc https://doi.org/10.1016/j.tetlet.2014.05.104 Zobrazit plný text záznamu Full Text from ScienceDirect