Fabrication and characterization of extruded and spheronized beads containing carbopol® 974P, NF resin

Autor:	Manzer J. Durrani, Michelle Y. Chow, Steven H. Neau
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Aqueous solution Materials science Pharmaceutical Science Electrolyte Polymer Strong electrolyte chemistry.chemical_compound Chemical engineering chemistry Ionic strength Polymer chemistry Wetting Dissolution Acrylic acid
Zdroj:	International Journal of Pharmaceutics. 131:47-55
ISSN:	0378-5173
DOI:	10.1016/0378-5173(95)04293-8
Popis:	Carbopol® 974P, NF resin is a synthetic, cross-linked, acrylic acid polymer. It becomes tacky when wetted, which introduces handling difficulties with techniques involving water or other fluid. To reduce tack, the water for wetting was replaced by an aqueous solution of a strong electrolyte. The effect of the concentration and type of electrolyte on the adhesive force of the wet mass was measured. A correlation was found between the charge density of the cation and the minimum salt concentration necessary to eliminate problems associated with tack. Beads containing chlorpheniramine maleate, Carbopol®, Avicel PH101, and electrolytes were successfully manufactured by extrusionspheronization. The Carbopol® concentration, as well as the pH and ionic strength of the dissolution medium and the rotation speed of the paddles, can modify drug release.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::122c854990c92a5f87529d52f9ca5fee https://doi.org/10.1016/0378-5173(95)04293-8 Zobrazit plný text záznamu Full Text from ScienceDirect