BRM cocktail treatment using PSK and OK432 significantly up-regulates the migration activity in human dendritic cells without losing effective CTL induction

Autor:	Takeo Hasegawa, Norio Kanzaki, Mika Hoshino, Yutaka Shio, Mitsukazu Gotoh, Kazuya Ise, Seigo Kashimura, Hiroyuki Suzuki, Jun Ohsugi, Atsushi Yonechi, Hiroshi Yaginuma, Mitsunori Higuchi
Rok vydání:	2011
Předmět:	Cancer Research business.industry medicine.medical_treatment Cancer chemical and pharmacologic phenomena hemic and immune systems Immunotherapy Dendritic cell medicine.disease CTL Oncology Immunology medicine Pharmacology (medical) business
Zdroj:	Annals of Cancer Research and Therapy. 19:1-8
ISSN:	1880-5469 1344-6835
DOI:	10.4993/acrt.19.1
Popis:	One of the major factors for successful DCs immunotherapy is thought to be the maintenance of the migratory activity of matured DCs. We evaluated the effectiveness of PSK on OK432-activated DCs, in terms of maturation, migration and induction of CTLs. When DCs were treated with both OK432 and PSK, migration ability of the DCs were significantly high as compared to OK432 alone preserving the beneficial effect of OK432 treatment. BRM cocktail treatment with OK432 and PSK induced high level of migration activity in activated DCs, suggesting a potential protocol for more effective DCs immunotherapy for cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::12239a1181ff7d1f6b83e17dec978e77 https://doi.org/10.4993/acrt.19.1 Zobrazit plný text záznamu