Human papillomavirus type 5 is commonly present in immunosuppressed and immunocompetent individuals
| Autor: | Anne Russell, Adèle C. Green, J.N. Bouwes Bavinck, Linda H.C. Mulder, Ingeborg L.A. Boxman, J. Ter Schegget |
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| Rok vydání: | 1999 |
| Předmět: |
education.field_of_study
integumentary system medicine.medical_treatment Population virus diseases Immunosuppression Dermatology Biology medicine.disease female genital diseases and pregnancy complications Virus law.invention law Psoriasis Immunology medicine Immunocompetence Skin cancer education Nested polymerase chain reaction Polymerase chain reaction |
| Zdroj: | British Journal of Dermatology. 141:246-249 |
| ISSN: | 0007-0963 |
| DOI: | 10.1046/j.1365-2133.1999.02972.x |
| Popis: | DNA of a wide spectrum of epidermodysplasia verruciformis-associated human papillomavirus (HPV) types (EV-HPV) has been detected in skin lesions and plucked hairs from both immunosuppressed and a considerable proportion of non-immunosuppressed persons. Recently, the skin of psoriatic patients was claimed to be an important reservoir for a particular EV-HPV type, HPV 5, which is considered as a high-risk HPV type for skin carcinomas. In the present study, we analysed plucked hairs from immunosuppressed renal transplant patients and immunocompetent individuals, utilizing an HPV 5-specific nested polymerase chain reaction. HPV 5 was detected in hairs derived from 14 of 31 (45%) immunosuppressed patients and 21 of 135 (16%) immunocompetent individuals. Both the immunosuppressed and the immunocompetent groups consisted of individuals with and without non-melanoma skin cancer. HPV 5 DNA was detected in similar proportions of hair samples plucked from individuals with and without skin cancer in either group. Our results indicate that HPV 5 is commonly present in the population. The role of HPV 5 in the pathogenesis of skin carcinomas and psoriasis remains to be established. |
| Databáze: | OpenAIRE |
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