Chromatographic profile and antioxidant and enzyme inhibitory activity of Sideritis leptoclada: An endemic plant from Turkey
| Autor: | Saliha Seyma Sahinler, Mehmet Sabih Ozer, Bektas Tepe, Cengiz Sarikurkcu, Erman Salih Istifli |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Antioxidant biology Traditional medicine medicine.medical_treatment Tyrosinase Ethyl acetate Plant Science biology.organism_classification Antimicrobial 01 natural sciences 0104 chemical sciences Solvent 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Verbascoside Chlorogenic acid chemistry medicine Sideritis 010606 plant biology & botany |
| Zdroj: | South African Journal of Botany. 143:393-405 |
| ISSN: | 0254-6299 |
| DOI: | 10.1016/j.sajb.2021.03.020 |
| Popis: | Sideritis species have been used for centuries for their antimicrobial, digestive, anti-ulcerogenic and anti-inflammatory properties. Therefore, in this study, it was aimed to evaluate the chemical composition, antioxidant and enzyme inhibitory activities of solvent extracts of S. leptoclada O. Schwarz & P.H. Davis, an endemic species. It was determined that methanol (MeOH) and water extracts contained high amounts of chlorogenic acid and verbascoside, while the ethyl acetate (EtOAc) extract contained high amounts of 4-hydroxybenzoic and vanilic acids. The water extract showed the highest antioxidant activity in almost all parameters. Inhibitory activity of the MeOH extract on tyrosinase was 1.04 mg/ml, which was the highest value in this experiment. On the other hand, in α-amylase inhibitory assay, the EtOAc extract showed an activity of 2.21 mg/ml. Docking analysis showed that verbascoside can be an effective tyrosinase and α-amylase inhibitory agent. |
| Databáze: | OpenAIRE |
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