Treatment of metastatic retinoblastoma with paclitaxel. Preliminary results of a pilot study with seven patients
| Autor: | Roberto Rivera-Luna, J. Amador Zarco, M. E. Flores-Rojo, C. Juarez-Echenique, Carlos Leal-Leal |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Chemotherapy medicine.medical_specialty business.industry Mortality rate medicine.medical_treatment medicine.disease Metastatic Retinoblastoma Metastasis Surgery chemistry.chemical_compound Oncology Paclitaxel chemistry medicine Recurrent disease Prospective cohort study business Pathological |
| Zdroj: | Journal of Clinical Oncology. 22:8569-8569 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | 8569 Background: Metastatic retinoblastoma has a very high mortality rate in most of the cases in spite that international efforts have been made with different chemotherapy regimens. Only high doses of chemotherapy followed by steam cells rescue have proved to provide long lasting survival. The purpose of the current work is to present a preliminary report in a small number of patients. Methods: In a prospective study patients with pathological diagnosis of metastatic retinoblastoma were included, regardless of having recurrent disease or metastasis at time of diagnosis. Once the staging procedure with imaging was performed, the patients were treated with paclitaxel as a single agent at a dose of 150 mg/m2 days 1, 4 and 7 days every 21 days from 2–6 courses. Results: . At the present time 7 patients were registered into the study. Their age ranged from 10 to 60 months old with a mean of 36 months and SD of 15 months. Six were boys and 1 girl. The time prior to develop metastasis was 11 months and a SD of... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|